Alopecia areata (AA) is an autoimmune condition of hair loss.
Our research focuses on the epidemiology of AA, its impact on patients, and the identification and promotion of effective therapies.
We’ve evaluated the risk of skin cancer and cardiovascular disease in patients with AA, and developed validated self-diagnostic tools that have been used in studies evaluating disease prevalence conducted with industry partners.
In studying the impact of AA on patients, we have identified that 60% of patients with AA report that the disease is a major financial burden, with one of three patients cutting down spending for food and clothes, and one out of five either skipping payments on other bills or selling possessions to manage medical expenses from AA. Many patients who are dissatisfied with current medical treatments use alternative therapies, wigs, and other cosmetic products. Despite these efforts, AA continues to have severe impact on patients’ mental health and sexual quality of life.
In addition to conducting clinical research on alopecia areata, Dr. Mostaghimi is a principal investigator for several clinical trials testing new therapeutics for patients with AA.
Creadore A, Manjaly P, Li SJ, Joyce C, Huang KP, Mostaghimi A. Evaluating Areas of Preferred Hair Loss: Potential Implications for Rating Alopecia Severity. JAMA Dermatol. Published online September 09, 2020. doi:10.1001/jamadermatol.2020.2930
Tkachenko E, Okhovat JP, Manjaly P, Huang KP, Senna MM, Mostaghimi A. Complementary & Alternative Medicine for Alopecia Areata: A Systematic Review. Journal of the American Academy of Dermatology. 2019.
Li SJ, Mostaghimi A, Tkachenko E, Huang KP. Association of Out-of-Pocket Health Care Costs and Financial Burden for Patients With Alopecia Areata. JAMA dermatology. 2019;155(4):493-494.
Li SJ, Huang KP, Joyce C, Mostaghimi A. The Impact of Alopecia Areata on Sexual Quality of Life. International journal of trichology. 2018;10(6):271-274.
Li DG, Huang KP, Xia FD, et al. Development and pilot-testing of the Alopecia Areata Assessment Tool (ALTO). PloS one. 2018;13(6):e0196517.
Hussain ST, Mostaghimi A, Barr PJ, Brown JR, Joyce C, Huang KP. Utilization of Mental Health Resources and Complementary and Alternative Therapies for Alopecia Areata: A U.S. Survey. International journal of trichology. 2017;9(4):160-164.
Mostaghimi A, Qureshi S, Joyce C, Guo Y, Huang KP. Reduced incidence of skin cancer in patients with alopecia areata: A retrospective cohort study. Cancer epidemiology. 2016;41:129-131.
Huang KP, Joyce CJ, Topaz M, Guo Y, Mostaghimi A. Cardiovascular risk in patients with alopecia areata (AA): A propensity-matched retrospective analysis. Journal of the American Academy of Dermatology. 2016;75(1):151-154.
Department of Dermatology
Brigham and Women’s Hospital
Boston, MA, 02215